Bhimsen Rout, PhDScientist (Senior Research Fellow)
Tissue Technologies
Welcome to the Research Milestone of "Bhimsen Rout"
Overview of Our Research
Research Interest
My research Interest focus on designing synthetic functional molecules that can interact with various analytes/bioanalytes (DNA, peptides, proteins) to understand their function and can compute change in optical signals logically as smart molecular devices. In addition, I have interest in covalent conjugation of peptide(s)/DNA(s) with drugs and their targeted delivery (for diagnosis and therapy) to melanoma/wound/lesion disorder tissues that are located at various depth of skin.
Miniaturized Information Processing Device
Pattern-generating molecule can act as miniaturized information processing device such as keypad lock, encoder-decoder, performing steganography etc. Recently, to hide (encrypt) and reveal (decryption) a set of data was achieved by using a pattern-generating chromophore that have ability to interact with multiple analytes as input and generate absorption pattern as output signals.
Targeted Photodynamic Therapy
Photodynamic therapy is a non-invasive module that is driven by photosensitizer based drug and specific wavelength of light. By covalently conjugating these drug molecules to a peptide i.e. a derivative of melano-stimulating hormone (MSH) that direct towards melanocotin-1 (MC1) receptor which over-expressed in melanoma cells, more targeted and less collateral damage was achieved using LED light of precise wavelengths. This therapeutic module has potential to treat lentigo maligna melanoma.
List of publications
Physical and compositional analysis of differently cultured 3D skin equivalents by confocal Raman spectroscopy
Yuri Dancik, Bhimsen Rout, Sriram Gopu, Frank Ho, Paul L. Bigliardi, Mei Bigliardi-Qi, Analyst, 2018,143, 1065-1076.
An intramolecular Tryptophan-condensation approach for peptide stapling
Eunice Y.-L. Hui, Bhimsen Rout, Yaw Sing Tan, Chandra S. Verma, Charles W. Johannes, Kok-Ping Chan, Org. Biomol. Chem., 2018, 16, 389-392.
Investigating endogenous μ-opioid receptors in human keratinocytes as pharmacological targets using fluorescent ligand
Cheryl Leong, Bhimsen Rout, Christine Neumann, Srinivas Ramasamy, Lim Yi Wee, Mei Bigliardi-Qi, Paul L. Bigliardi, Plos One, 2017, 12(12): e0188607.
Specific targeting of melanocytes and melanoma cells by photodynamic therapy using ligated photosensitizers directed against MC1 receptors
Bhimsen Rout*, Paul L. Bigliardi, Aakanksha Pant, Viknish Kutty, Ramasamy Srinivas, Alex N. Eberle, Brendan A. Burkett, Mei Bigliardi, Scientific Reports, 2017, 7, 15750.
Synthetic peptide drugs for targeting skin cancer: Malignant melanoma and melanotic lesions
Alex N. Eberle, Bhimsen Rout, Mei Bigliardi-Qi, Paul L. Bigliardi, Curr. Med. Chem., 2017, 24, 1-30.
An expedient multiple information processing pattern-generating chromophore
Bhimsen Rout*, Mei Bigliardi-Qi, Paul Lorenz Bigliardi, Sensors and Actuators B: Chemical, 2017, 251,164-170.
A miniaturized therapeutic chromophore for multiple metal pollutant sensing, pathological metal diagnosis and logical computing
Bhimsen Rout* Scientific Reports, 2016, 6, 27115. DOI: 10.1038/srep27115.
Invited to write a highlight in Synpacts, Themie-Connect publisher.
Protein Recognition by Bivalent, ‘Turn-On’ Fluorescent Molecular Probes
Linor Unger-Angel, Bhimsen Rout, Tal Ilani, Miriam Eisenstein, Leila Motiei, David Margulies, Chemical Science. 2015, 6, 5419-5426.
Authorizing multiple chemical passwords by a combinatorial molecular keypad lock
Bhimsen Rout, Petr Milko, Mark A. Iron, Leila Motiei, David Margulies, J. Am. Chem. Soc., 2013, 135, 15330-15333.
Highlighted in PHY.ORG
Highlighted in Synpacts
Medication detection by a combinatorial fluorescent molecular sensor
Bhimsen Rout, Linor Unger, Gadi Armony, Mark A. Iron, David Margulies, Angew. Chem. Int. Ed., 2012, 51, 12477-12481.
Highlighted as back cover picture
Highlighted by Faculty of 1000
Invited highlight paper for Synpacts
A formal total synthesis of (±)-neplanocin A
Faiz Ahmed Khan, Bhimsen Rout, J. Org. Chem., 2007, 72, 7011-7013.
Synthesis of a novel bowl like bis γ-lactone
Faiz Ahmed Khan, Vineet Dwivedi, Bhimsen Rout, Tetrahedron Lett., 2007, 48, 207-209.
Total synthesis of (±)-pentenomycin
Faiz Ahmed Khan, Bhimsen Rout, Tetrahedron Lett., 2006, 47, 5251-5253.
A short and stereo-selective synthesis of functionalized Pentenomycin derivatives
Faiz Ahmed Khan, Jyotirmayee Dash, Bhimsen Rout, Tetrahedron Lett, 2004, 45, 9285-9288.
Pattern-generating unimolecular sensors: For future differential sensing and molecular computing
Bhimsen Rout*, Paul L. Bigliardi, Synlett, 2017, 28, 1005-1010.
Combinatorial fluorescent molecular sensors: The road to differential sensing at the molecular level
Bhimsen Rout, Leila Motiei, David Margulies, Synlett, 2014, 25 (8), 1050-1054.
Contact us:
Thanks for your interest in our research. Get in touch with us for any questions or comments regarding our work and publications. We’d love to hear from you.
8 Biomedical Grove, Imunnos #06-06
Singapore, 138648
Singapore
+65-82978161
